Research Paper Volume 13, Issue 9 pp 12996—13005

Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2

Azilsartan mitigated ox-LDL-induced endothelial permeability of HUVECs. Cells were stimulated with ox-LDL (100 μg/mL) in the presence or absence of Azilsartan (3, 6 μM) for 24 hours. Endothelial monolayer permeability was measured by FITC-dextran permeation (****, P

Figure 5. Azilsartan mitigated ox-LDL-induced endothelial permeability of HUVECs. Cells were stimulated with ox-LDL (100 μg/mL) in the presence or absence of Azilsartan (3, 6 μM) for 24 hours. Endothelial monolayer permeability was measured by FITC-dextran permeation (****, P<0.0001 vs. vehicle group; ##, ###, P<0.01, 0.001 vs. ox-LDL group, N=6 for each group).