Research Paper Volume 13, Issue 10 pp 13822—13845

Development and validation of epithelial mesenchymal transition-related prognostic model for hepatocellular carcinoma

Gene methylation analysis of the gene signature between the tumor and normal tissues. (A) beneficial and harmful methylation sites in BDNF; (B) beneficial and harmful methylation sites in EOMES; (C) beneficial and harmful methylation sites in ZNF746 gene; (D) beneficial and harmful methylation sites in PIK3R1gene; (E) beneficial and harmful methylation sites in TSC2 gene; (F) beneficial and harmful methylation sites in MYCN gene; (G) The methylation of BDNF gene significantly correlated with the OS of HCC patients; (H) The methylation of PIK3R1 gene significantly correlated with the OS of HCC patients. HCC, hepatocellular carcinoma; OS, overall survival; ROC, receiver operating characteristic curve.

Figure 7. Gene methylation analysis of the gene signature between the tumor and normal tissues. (A) beneficial and harmful methylation sites in BDNF; (B) beneficial and harmful methylation sites in EOMES; (C) beneficial and harmful methylation sites in ZNF746 gene; (D) beneficial and harmful methylation sites in PIK3R1gene; (E) beneficial and harmful methylation sites in TSC2 gene; (F) beneficial and harmful methylation sites in MYCN gene; (G) The methylation of BDNF gene significantly correlated with the OS of HCC patients; (H) The methylation of PIK3R1 gene significantly correlated with the OS of HCC patients. HCC, hepatocellular carcinoma; OS, overall survival; ROC, receiver operating characteristic curve.