Research Paper Volume 13, Issue 8 pp 10973—10988

Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional

Grey matter volume in the default mode and executive control networks moderates the relationship between white matter hyperintensity volume and memory at low white matter hyperintensity load. In tercile 1, executive control network (A) RDLPFC, (C) LDLPFC, (D) RPPC and default mode network (B) PCUN grey matter volume moderated the relationship between memory (ADAS delayed recall, ADAS immediate recall) impairment and increasing WMH load. Abbreviations: ADAS, Alzheimer’s disease assessment scale; WMH, white matter hyperintensity; TIV, total intracranial volume; LDLPFC, left dorsolateral prefrontal cortex; RDLPFC, right dorsolateral prefrontal cortex; RPPC, right posterior parietal cortex; PCUN, precuneus; GMV, grey matter volume.

Figure 2. Grey matter volume in the default mode and executive control networks moderates the relationship between white matter hyperintensity volume and memory at low white matter hyperintensity load. In tercile 1, executive control network (A) RDLPFC, (C) LDLPFC, (D) RPPC and default mode network (B) PCUN grey matter volume moderated the relationship between memory (ADAS delayed recall, ADAS immediate recall) impairment and increasing WMH load. Abbreviations: ADAS, Alzheimer’s disease assessment scale; WMH, white matter hyperintensity; TIV, total intracranial volume; LDLPFC, left dorsolateral prefrontal cortex; RDLPFC, right dorsolateral prefrontal cortex; RPPC, right posterior parietal cortex; PCUN, precuneus; GMV, grey matter volume.