Research Paper Volume 13, Issue 8 pp 10973—10988

Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional

Grey matter volume in the executive control network moderates the relationship between white matter hyperintensity volume and executive function at high white matter hyperintensity load. The association between executive function (frontal assessment battery) decline and increasing WMH load in tercile 3 was moderated primarily by executive control network (A) LDLPFC, (B) RDLPFC and (C) LPPC grey matter volume. Abbreviations: WMH, white matter hyperintensity; TIV, total intracranial volume; LDLPFC, left dorsolateral prefrontal cortex; RDLPFC, right dorsolateral prefrontal cortex; LPPC, left posterior parietal cortex; GMV, grey matter volume.

Figure 3. Grey matter volume in the executive control network moderates the relationship between white matter hyperintensity volume and executive function at high white matter hyperintensity load. The association between executive function (frontal assessment battery) decline and increasing WMH load in tercile 3 was moderated primarily by executive control network (A) LDLPFC, (B) RDLPFC and (C) LPPC grey matter volume. Abbreviations: WMH, white matter hyperintensity; TIV, total intracranial volume; LDLPFC, left dorsolateral prefrontal cortex; RDLPFC, right dorsolateral prefrontal cortex; LPPC, left posterior parietal cortex; GMV, grey matter volume.