Research Paper Volume 13, Issue 8 pp 10973—10988

Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional

Grey matter volume in the default mode and executive control networks moderates the relationship between white matter hyperintensity volume and memory at high white matter hyperintensity load. In tercile 3, (A) default mode network PCC and (B) executive control network LDLPFC grey matter volume moderated the relationship between memory (ADAS delayed recall, ADAS immediate recall) impairment and increasing WMH load. Abbreviations: ADAS, Alzheimer’s disease assessment scale; WMH, white matter hyperintensity; TIV, total intracranial volume; LDLPFC, left dorsolateral prefrontal cortex; RDLPFC, PCC, posterior cingulate cortex; GMV, grey matter volume.

Figure 4. Grey matter volume in the default mode and executive control networks moderates the relationship between white matter hyperintensity volume and memory at high white matter hyperintensity load. In tercile 3, (A) default mode network PCC and (B) executive control network LDLPFC grey matter volume moderated the relationship between memory (ADAS delayed recall, ADAS immediate recall) impairment and increasing WMH load. Abbreviations: ADAS, Alzheimer’s disease assessment scale; WMH, white matter hyperintensity; TIV, total intracranial volume; LDLPFC, left dorsolateral prefrontal cortex; RDLPFC, PCC, posterior cingulate cortex; GMV, grey matter volume.