Research Paper Volume 13, Issue 8 pp 10891—10919

Dietary-challenged mice with Alzheimer-like pathology show increased energy expenditure and reduced adipocyte hypertrophy and steatosis

Experimental design and nutritional values of diets. (A) Experimental procedures: In week 0, baseline measurements of body composition (NMR) and indirect calorimetry (LM) were conducted, as well as the first blood withdrawal (BL). Diets were fed from week 1 to 20. Body weight was assessed weekly. Monthly, NMR and BL were performed. In week 12 and 20, mice additionally underwent LM measurements and glucose tolerance tests (GTT). (B) Group layout and diet composition: 4-6-week old transgenic APP23 and WT mice were assigned to either normal-control diet (NCD), high-sucrose diet (HSD) or high-fat diet (HFD). Shown n numbers represent animal numbers for all measurements in living animals and in the animals’ blood.

Figure 1. Experimental design and nutritional values of diets. (A) Experimental procedures: In week 0, baseline measurements of body composition (NMR) and indirect calorimetry (LM) were conducted, as well as the first blood withdrawal (BL). Diets were fed from week 1 to 20. Body weight was assessed weekly. Monthly, NMR and BL were performed. In week 12 and 20, mice additionally underwent LM measurements and glucose tolerance tests (GTT). (B) Group layout and diet composition: 4-6-week old transgenic APP23 and WT mice were assigned to either normal-control diet (NCD), high-sucrose diet (HSD) or high-fat diet (HFD). Shown n numbers represent animal numbers for all measurements in living animals and in the animals’ blood.