Research Paper Volume 13, Issue 10 pp 13846—13858

Esophageal carcinoma cell-excreted exosomal uc.189 promotes lymphatic metastasis

Exosomal uc.189 promotes lymphangiogenesis. Illustrative model showing the mechanism whereby ESCC-secreted exosomal uc.189 promotes lymphangiogenesis by downregulating lymphatic EPHA2 expression that then facilitates lymphatic metastasis.

Figure 7. Exosomal uc.189 promotes lymphangiogenesis. Illustrative model showing the mechanism whereby ESCC-secreted exosomal uc.189 promotes lymphangiogenesis by downregulating lymphatic EPHA2 expression that then facilitates lymphatic metastasis.