Figure 4. Development of a prognostic signature for BC based on 7 ZNF genes. (A) Distribution and median value of the risk scores in the TCGA cohort. (B) Survival status of patients in the different risk groups. (C) Heatmap of the expression profiles of the 7 ZNF genes included in the prognostic signature. (D) Time-dependent ROC curve of the 7-gene signature. (E) Survival analysis of the signature-defined risk groups. (F) Univariable and (G) multivariable analyses adjusting for risk score, age, gender, tumor stage, and TNM.