Review Volume 13, Issue 9 pp 13359—13371

Gut microbial involvement in Alzheimer's disease pathogenesis

Potential contribution of the gut microbiota to the pathogenesis of Alzheimer's disease. The gut microbiota can affect the occurrence and progression of AD through metabolites, neurotransmitters, and proinflammatory mediators to promote Aβ aggregation, accumulation of hyperphosphorylated tau, and chronic neuroinflammation. Parts of the figure are adapted from SMART (Servier Medical Art: <a href="https://smart.servier.com" target="

Figure 1. Potential contribution of the gut microbiota to the pathogenesis of Alzheimer's disease. The gut microbiota can affect the occurrence and progression of AD through metabolites, neurotransmitters, and proinflammatory mediators to promote Aβ aggregation, accumulation of hyperphosphorylated tau, and chronic neuroinflammation. Parts of the figure are adapted from SMART (Servier Medical Art: https://smart.servier.com), licensed under a Creative Common Attribution 3.0 Generic License.