Research Paper Volume 13, Issue 9 pp 13225—13238

TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways

Knockdown of TRIM14 inactivated AKT and STAT3 pathways. A375 cells were transfected with siRNA-NC and siRNA-TRIM14, respectively. The protein expression of PTEN, p-PI3K/PI3K, p-AKT/AKT, p-STAT3/STAT3 was detected using western blot. **, ***p

Figure 6. Knockdown of TRIM14 inactivated AKT and STAT3 pathways. A375 cells were transfected with siRNA-NC and siRNA-TRIM14, respectively. The protein expression of PTEN, p-PI3K/PI3K, p-AKT/AKT, p-STAT3/STAT3 was detected using western blot. **, ***p < 0.01, 0.001 vs siRNA-NC.