Research Paper Volume 13, Issue 9 pp 13264—13286

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

circRNA

Figure 3. circRNA_102481 is mainly secreted via exosomes. (A, B) circRNA_102481 was unregulated in EGFR-TKIs resistant cells (PC9/GR and HCC827/ER), **p< 0.01 versus matched sensitive cells (PC9 and HCC827). (C, D) circRNA_102481 was significantly up-regulated in exosomes of EGFR-TKIs resistant cells (PC9/GR and HCC827/ER), **p< 0.01 versus matched sensitive cells (PC9 and HCC827).