Research Paper Volume 13, Issue 9 pp 13264—13286

Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer

Functional validation assay of exosomes circRNA

Figure 6. Functional validation assay of exosomes circRNA_102481 on EGFR-TKIs resistant cells in vitro (n=3).(A, B) MTT assay showed the effects of exosomes circRNA_102481 on EGFR-TKIs resistant cell proliferation. (C, D) Annexin V/PI assay showed the effects of exosomes circRNA_102481 on EGFR-TKIs resistant cell apoptosis. si-circRNA_102481: siRNA targeting circRNA_102481. *p<0.05 versus si-NC group.