Research Paper Volume 13, Issue 11 pp 14940—14967

Identification of key transcriptome biomarkers based on a vital gene module associated with pathological changes in Alzheimer’s disease

Expression and functional analyses of GNA13, ROCK2 and GJA1. (A, B) Representative immunoblots (A) and densitometry (B) analysis of GNA13, ROCK2, and GJA1 expression in the hippocampus of 5XFAD mice and LM mice. (C, D) Representative immunoblots (C) and densitometry (D) analysis of GNA13, ROCK2, and GJA1 expression in the hippocampus of 5XFAD mice of various ages. (E) Top 3 gene sets (according to NES) enriched in the high-expression group of GNA13. (F) Top 3 gene sets (according to NES) enriched in the high-expression group of GJA1. Data were presented as the mean ± SD of five mice in each group. * p p p

Figure 6. Expression and functional analyses of GNA13, ROCK2 and GJA1. (A, B) Representative immunoblots (A) and densitometry (B) analysis of GNA13, ROCK2, and GJA1 expression in the hippocampus of 5XFAD mice and LM mice. (C, D) Representative immunoblots (C) and densitometry (D) analysis of GNA13, ROCK2, and GJA1 expression in the hippocampus of 5XFAD mice of various ages. (E) Top 3 gene sets (according to NES) enriched in the high-expression group of GNA13. (F) Top 3 gene sets (according to NES) enriched in the high-expression group of GJA1. Data were presented as the mean ± SD of five mice in each group. * p < 0.05, ** p < 0.01 and **** p < 0.0001.