Research Paper Volume 13, Issue 9 pp 12334—12358

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

Cardiac aging is associated with decreased mitochondrial function and increased mtDNA and telomere damage. (A) Quantification of NAD+ in the heart lysate of Young and Old mice. Values are mean ± SE, n = 8-10. (B) Relative mitochondrial citrate synthase activity in the heart of Young and Old mice. Values are mean ± SE, n = 5. (C) Relative mitochondrial DNA lesions in the heart of Young and Old mice. (D) 8-Oxo-dG content in the DNA of the whole heart of Young and Old mice. All values are mean ± SE, n = 5. (E) Relative telomere length of Young and Old mice. Values are mean ± SE, n = 5.

Figure 2. Cardiac aging is associated with decreased mitochondrial function and increased mtDNA and telomere damage. (A) Quantification of NAD+ in the heart lysate of Young and Old mice. Values are mean ± SE, n = 8-10. (B) Relative mitochondrial citrate synthase activity in the heart of Young and Old mice. Values are mean ± SE, n = 5. (C) Relative mitochondrial DNA lesions in the heart of Young and Old mice. (D) 8-Oxo-dG content in the DNA of the whole heart of Young and Old mice. All values are mean ± SE, n = 5. (E) Relative telomere length of Young and Old mice. Values are mean ± SE, n = 5.