Research Paper Volume 13, Issue 10 pp 14109—14130

Rheumatoid arthritis and osteoporosis: a bi-directional Mendelian randomization study

Workflow of bi-directional MR analysis. (A) The fundamental idea of MR analysis: If we cannot randomize the exposure, we can find a randomized instrumental variable to disentangle (B) Workflow of our bi-directional MR analysis. MR: Mendelian randomization; BMD: Bone mineral density; RA: Rheumatoid arthritis.

Figure 1. Workflow of bi-directional MR analysis. (A) The fundamental idea of MR analysis: If we cannot randomize the exposure, we can find a randomized instrumental variable to disentangle (B) Workflow of our bi-directional MR analysis. MR: Mendelian randomization; BMD: Bone mineral density; RA: Rheumatoid arthritis.