Research Paper Volume 13, Issue 10 pp 14258—14276

LncRNA LOC100129620 promotes osteosarcoma progression through regulating CDK6 expression, tumor angiogenesis, and macrophage polarization

LncRNA LOC100129620 regulates osteosarcoma progression in vivo. (A) U2OS cells with LOC100129620 overexpression or knockdown were transplanted subcutaneously into nude mice (n = 5). (B) Tumor weight of osteosarcoma with LOC100129620 overexpression or knockdown. (C) Tumor weight of osteosarcoma with LOC100129620 overexpression. (D) Tumor weight of osteosarcoma with LOC100129620 knockdown. Statistical analysis was conducted using Student’s t-test. Values are means ± SD. **p ##P ΔΔP

Figure 4. LncRNA LOC100129620 regulates osteosarcoma progression in vivo. (A) U2OS cells with LOC100129620 overexpression or knockdown were transplanted subcutaneously into nude mice (n = 5). (B) Tumor weight of osteosarcoma with LOC100129620 overexpression or knockdown. (C) Tumor weight of osteosarcoma with LOC100129620 overexpression. (D) Tumor weight of osteosarcoma with LOC100129620 knockdown. Statistical analysis was conducted using Student’s t-test. Values are means ± SD. **p < 0.01, pLVX-Vector group compared with pLVX-LOC100129620 group; ##P < 0.01, pLKO.1-Vector group compared with pLKO.1-sh1 group; ΔΔP < 0.01, pLKO.1-Vector group compared with pLKO.1-sh1 group.