Research Paper Volume 13, Issue 10 pp 14277—14288

Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair

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Figure 3.

UCHL3 knockdown enhanced radio-sensitivity of non-small cell lung cancer cells in vivo. (A) Images of dissected tumors from nude mice. (B, C) Tumor growth curve and (B) tumor weight (C) are shown. (D) Body weight of mice treated with vehicle control, combination of transfected with sh-NC and radiation, combination of transfected with sh-UCHL3 and radiation. (E) Western blot analysis of γ-H2AX, p-Chk2, Chk2 after H460 cells treated with indicated treatment. β-actin was used as a loading control. Data are presented as the mean ± s.d. of five mice per group. **P < 0.01, n.s. no significance.