Research Paper Volume 13, Issue 10 pp 14342—14354

LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p in bone-invasive pituitary adenomas

The expression of TNF-α, MEG8 and miR-454-3p in PAs and the relationship between the expression of TNF-α and the prognosis of patients. (A) The preoperative images of NIPAs and BIPAs. Western blot (B) and IHC (C) were used to detect the expression of TNF-α in BIPAs and NIPAs. (D) Kaplan-Meier plotter was used to analyze the regrowth-free curves of patients in TNF-α high/low groups. (E) RT-qPCR was used to detect the expression of TNF-α, MEG8 and miR-454-3p in BIPAs and NIPAs. ***P

Figure 1. The expression of TNF-α, MEG8 and miR-454-3p in PAs and the relationship between the expression of TNF-α and the prognosis of patients. (A) The preoperative images of NIPAs and BIPAs. Western blot (B) and IHC (C) were used to detect the expression of TNF-α in BIPAs and NIPAs. (D) Kaplan-Meier plotter was used to analyze the regrowth-free curves of patients in TNF-α high/low groups. (E) RT-qPCR was used to detect the expression of TNF-α, MEG8 and miR-454-3p in BIPAs and NIPAs. ***P < 0.001.