Research Paper Volume 13, Issue 10 pp 14342—14354

LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p in bone-invasive pituitary adenomas

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Figure 6.

Mechanism and function of TNF-α in BIPAs progress. LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p, and then TNF-α directly induce osteoclast differentiation in BIPAs, which further leads to bone destruction.