Research Paper Volume 13, Issue 11 pp 15044—15060

Integrated analysis of long non-coding RNAs (lncRNAs) and mRNA expression profiles identifies lncRNA PRKG1-AS1 playing important roles in skeletal muscle aging

Validation of MyoD (A) and key DElncRNAs (B) by qRT-PCR in a dexamethasone-induced muscle atrophy cell model. Different concentrations of dexamethasone (Dex, 5 mM, 10 mM and 15 mM) were added in human skeletal muscle myoblasts and incubated for 48 h. Difference among groups was analyzed by ANOVA with Dunnett’s multiple comparison test. * P P P

Figure 6. Validation of MyoD (A) and key DElncRNAs (B) by qRT-PCR in a dexamethasone-induced muscle atrophy cell model. Different concentrations of dexamethasone (Dex, 5 mM, 10 mM and 15 mM) were added in human skeletal muscle myoblasts and incubated for 48 h. Difference among groups was analyzed by ANOVA with Dunnett’s multiple comparison test. * P < 0.05, ** P < 0.01, ***P < 0.001, compared with control group.