Figure 7. VEGFA knockdown significantly inhibited CRC progression. (A) VEGFA expression was downregulated in HCT116 and HCT8 cells transfected with siVEGFA-1 or siVEGFA-2. (B-E) VEGFA knockdown inhibited CRC cell proliferation (B), migration (C), invasion (D) and HUVECs tube formation (E). Data are shown as the meanv±SD of three independent experiments. *p<0.05, **p<0.01, ***p<0.001.