Research Paper Volume 13, Issue 10 pp 13421—13429

Systemic NF-κB-mediated inflammation promotes an aging phenotype in skeletal stem/progenitor cells

SSPC frequency declines in response to increased NF-κB-mediated inflammation. (A) SSPCs isolated from parabiosed animals six weeks post-surgery revealed that exposure to increased inflammation results in decreased SSPC number as revealed by colony forming unit (CFU) assays. (B) Nfkb1-/-WT and WTNfkb1-/- SSPCs gave rise to significantly fewer colonies than those isolated from the WTWT parabionts as revealed by CFU-f efficiency (n=3, *P

Figure 2. SSPC frequency declines in response to increased NF-κB-mediated inflammation. (A) SSPCs isolated from parabiosed animals six weeks post-surgery revealed that exposure to increased inflammation results in decreased SSPC number as revealed by colony forming unit (CFU) assays. (B) Nfkb1-/-WT and WTNfkb1-/- SSPCs gave rise to significantly fewer colonies than those isolated from the WTWT parabionts as revealed by CFU-f efficiency (n=3, *P < 0.05).