Research Paper Volume 13, Issue 11 pp 15240—15254

Depletion of SENP1-mediated PPARγ SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation

SENP1 depletion promotes intermittent hypoxia (IH)-induced cognitive decline. (A–D) Cognitive functions of mice with or without SENP1 knockdown under normoxic and IH conditions were analyzed using the Morris water maze test. Mice swam in the pool for 60 s on day 6, and other days’ test termination times were subject to the climbing platform. (A) There was no difference among the four experimental groups in average swimming speed throughout six consecutive days. (B) Latency was the time that mice first climbed onto the hidden platform or first passed through the area where the platform was located. (C) The percentage of time that mice spent in the quadrant where the platform was located versus the total time. (D) The frequency of passing through the area where the platform was located. **p p ##p +/+-IH group.

Figure 6. SENP1 depletion promotes intermittent hypoxia (IH)-induced cognitive decline. (AD) Cognitive functions of mice with or without SENP1 knockdown under normoxic and IH conditions were analyzed using the Morris water maze test. Mice swam in the pool for 60 s on day 6, and other days’ test termination times were subject to the climbing platform. (A) There was no difference among the four experimental groups in average swimming speed throughout six consecutive days. (B) Latency was the time that mice first climbed onto the hidden platform or first passed through the area where the platform was located. (C) The percentage of time that mice spent in the quadrant where the platform was located versus the total time. (D) The frequency of passing through the area where the platform was located. **p < 0.01, ***p < 0.001 versus the normoxia groups. ##p < 0.01 versus the SENP1+/+-IH group.