Research Paper Volume 13, Issue 11 pp 15320—15335

Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis

Prolonged administration of D-galactose induces gut microbial dysbiosis in mice. (A) The relative abundance of the top 10 gut microbial phyla in the WT and Mod group mice. (B) The relative abundance of the gut microbial genera based on the linear discriminant analysis (LDA) scores in the WT and Mod group mice. (C) LEfSe cladogram shows the most enriched gut bacterial genera in the WT and Mod group mice. Only taxons with LDA scores >4 and p-value B, C). Note: All data are represented as means ± SEM (n=15). The differences between groups were analyzed by unpaired Student's t-tests.

Figure 2. Prolonged administration of D-galactose induces gut microbial dysbiosis in mice. (A) The relative abundance of the top 10 gut microbial phyla in the WT and Mod group mice. (B) The relative abundance of the gut microbial genera based on the linear discriminant analysis (LDA) scores in the WT and Mod group mice. (C) LEfSe cladogram shows the most enriched gut bacterial genera in the WT and Mod group mice. Only taxons with LDA scores >4 and p-value <0.05 are represented in (B, C). Note: All data are represented as means ± SEM (n=15). The differences between groups were analyzed by unpaired Student's t-tests.