Figure 8. FGF7 induces osteosarcoma cell cycle and proliferation, EMT progression and secretion of inflammatory mediators. (A) The expression of FGF7 was measured by qRT-PCR assay. (B) Ectopic expression of FGF7 increased cell growth in the MG-63 cell. (C) The expression of ki-67 was measured by qRT-PCR assay. (D) Overexpression of FGF7 increased cell cycle in MG-63 cell. (E) Elevated expression of FGF7 suppressed E-cadherin expression and increased the expression of N-cadherin and vimentin in MG-63 cell. (F) The level of IL-1β was determined by ELISA assay. (G) The level of IL-6 was determined by ELISA assay. (H) The level of TGFβ was determined by ELISA assay. *p<0.05, **p<0.01 and ***p<0.001.