Research Paper Volume 13, Issue 11 pp 15511—15522

Propofol ameliorates renal ischemia/reperfusion injury by enhancing macrophage M2 polarization through PPARγ/STAT3 signaling

Propofol postconditioning reduces renal proinflammatory cytokine levels and increases macrophage M2 polarization marker expression in rats subjected to rI/R. Real-time PCR determination of relative renal mRNA expression levels of (A) TNF-α, (B) IL-6, (C) CXCL-10, (D) IL-10, (E) iNOS, (F) Arg1, and (G) Mrc1. *P

Figure 2. Propofol postconditioning reduces renal proinflammatory cytokine levels and increases macrophage M2 polarization marker expression in rats subjected to rI/R. Real-time PCR determination of relative renal mRNA expression levels of (A) TNF-α, (B) IL-6, (C) CXCL-10, (D) IL-10, (E) iNOS, (F) Arg1, and (G) Mrc1. *P < 0.05 between the indicated groups.