S100A8 and S100A9, both transcriptionally regulated by PU.1, promote epithelial-mesenchymal transformation (EMT) and invasive growth of dermal keratinocytes during scar formation post burn

Zhigang Xu; Chuantao Cheng; Ranran Kong; Yale Liu; Shuang Wang; Yuefeng Ma; Xin Xing

doi:doi:10.18632/aging.203112

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Research Paper Volume 13, Issue 11 pp 15523—15537

S100A8 and S100A9, both transcriptionally regulated by PU.1, promote epithelial-mesenchymal transformation (EMT) and invasive growth of dermal keratinocytes during scar formation post burn

Figure 6. S100A8 and S100A9 promoted scar development in PU.1^-/- burn model mice. (A) expression of PU.1, S100A8 and S100A9 proteins in the skin of WT and skin-specific PU.1 knockout (PU.1^-/- or ΔPU.1) mouse. The effect of overexpression of S100A8 or/and S100A9 on (B) expression of EMT marker proteins, (C) time of wound healing, (D) histopathological changes (by HE staining), (E) scar volume, (F) scar thickness, and (G) contents of collagens in PU.1^-/- burn model mice. *P < 0.05 vs. WT, ^#P < 0.05 vs. ΔPU.1+Vector.