Figure 6. S100A8 and S100A9 promoted scar development in PU.1-/- burn model mice. (A) expression of PU.1, S100A8 and S100A9 proteins in the skin of WT and skin-specific PU.1 knockout (PU.1-/- or ΔPU.1) mouse. The effect of overexpression of S100A8 or/and S100A9 on (B) expression of EMT marker proteins, (C) time of wound healing, (D) histopathological changes (by HE staining), (E) scar volume, (F) scar thickness, and (G) contents of collagens in PU.1-/- burn model mice. *P < 0.05 vs. WT, #P < 0.05 vs. ΔPU.1+Vector.