Research Paper Volume 13, Issue 11 pp 15538—15547

miR-34a inhibits melanoma growth by targeting ZEB1

miR-34a inhibits in vivo growth of melanoma by targeting ZEB1. (A, B) Tumor volume and weight in nude mice 28 days after injection with miR-34a and ZEB1 transfection (mean ± SEM; ** PPC) Immunofluorescence staining of ZEB1 showing increased ZEB1 expression in control group than in miR-34a group, and in miR-34a+ZEB1 group than in miR-34a group (** PPD, E) miR-34a could significantly down regulate ZEB1 expression. ZEB1 transfection attenuated the effect of miR-34a. Data are shown as mean ± SEM. ** PP

Figure 4. miR-34a inhibits in vivo growth of melanoma by targeting ZEB1. (A, B) Tumor volume and weight in nude mice 28 days after injection with miR-34a and ZEB1 transfection (mean ± SEM; ** P< 0.05 vs. control, ##P< 0.05 vs. miR-34a group). (C) Immunofluorescence staining of ZEB1 showing increased ZEB1 expression in control group than in miR-34a group, and in miR-34a+ZEB1 group than in miR-34a group (** P< 0.05 vs. control, ##P< 0.05 vs. miR-34a group). (D, E) miR-34a could significantly down regulate ZEB1 expression. ZEB1 transfection attenuated the effect of miR-34a. Data are shown as mean ± SEM. ** P< 0.05 vs. control, ##P< 0.05 vs. miR-34a group.