Research Paper Advance Articles

Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Levobupivacaine represses invasion and migration of NSCLC cells. (A–D) The A549 and A427 cells were treated with levobupivacaine (2 mM) or equal volume saline. (A and B) The cell migration and invasion were examined by transwell assays in the cells. (C and D) The migration and invasion were measured by wound healing assays in the cells. The wound healing proportion was shown. Data are presented as mean ± SD. Statistic significant differences were indicated: **P

Figure 2. Levobupivacaine represses invasion and migration of NSCLC cells. (AD) The A549 and A427 cells were treated with levobupivacaine (2 mM) or equal volume saline. (A and B) The cell migration and invasion were examined by transwell assays in the cells. (C and D) The migration and invasion were measured by wound healing assays in the cells. The wound healing proportion was shown. Data are presented as mean ± SD. Statistic significant differences were indicated: **P < 0.01.