Research Paper Advance Articles

Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Levobupivacaine attenuates the tumor growth of NSCLC in vivo. (A–D) The effect of levobupivacaine on tumor growth of NSCLC cells in vivo was analyzed by nude mice tumorigenicity assay by injected with the A549 cells. The mice were treated with levobupivacaine (40 μmol/Kg) or equal volume saline. (A) Representative images of dissected tumors from nude mice were presented. (B) The average tumor volume was calculated and shown. (C) The average tumor weight was calculated and shown. (D) The expression of p53 and β-actin was measured by Western blot analysis in the tumor tissues of the mice. Data are presented as mean ± SD. Statistic significant differences were indicated: *P **P

Figure 7. Levobupivacaine attenuates the tumor growth of NSCLC in vivo. (AD) The effect of levobupivacaine on tumor growth of NSCLC cells in vivo was analyzed by nude mice tumorigenicity assay by injected with the A549 cells. The mice were treated with levobupivacaine (40 μmol/Kg) or equal volume saline. (A) Representative images of dissected tumors from nude mice were presented. (B) The average tumor volume was calculated and shown. (C) The average tumor weight was calculated and shown. (D) The expression of p53 and β-actin was measured by Western blot analysis in the tumor tissues of the mice. Data are presented as mean ± SD. Statistic significant differences were indicated: *P < 0.05, **P < 0.01.