Research Paper Volume 13, Issue 13 pp 17442—17461

Prognostic signatures associated with high infiltration of Tregs in bone metastatic prostate cancer

PPI networks constructed by the DEGs from BM PCa and pathway function enrichment. Deregulated gene networks of GSE32269 (A) and GSE77930 (B). (C) Network of significant hub proteins screened from GSE32269. (D) Network of significant hub proteins screened from GSE77930. Red and green intensities indicate the degree of upregulation and downregulation, respectively. (E) Pathway enrichment in network C. (F) Pathway enrichment in network D.

Figure 3. PPI networks constructed by the DEGs from BM PCa and pathway function enrichment. Deregulated gene networks of GSE32269 (A) and GSE77930 (B). (C) Network of significant hub proteins screened from GSE32269. (D) Network of significant hub proteins screened from GSE77930. Red and green intensities indicate the degree of upregulation and downregulation, respectively. (E) Pathway enrichment in network C. (F) Pathway enrichment in network D.