Research Paper Volume 13, Issue 15 pp 19282—19292

Evaluation of the cargo contents and potential role of extracellular vesicles in osteoporosis

Plasma EVs concentrations correlate to BMD and gender. (A) EV concentration grouped by obtained BMD value. Linear regression analysis was performed for EV concentration using a cohort of 7 normal controls, 7 Osteopenia and 7 Osteoporotic patients. (B) EV concentration in male and female were compared between osteoporotic and non-osteoporotic individuals. (C) Effects of hindlimb unloading and salubrinal on EV concentration in a mouse model of osteoporosis.

Figure 2. Plasma EVs concentrations correlate to BMD and gender. (A) EV concentration grouped by obtained BMD value. Linear regression analysis was performed for EV concentration using a cohort of 7 normal controls, 7 Osteopenia and 7 Osteoporotic patients. (B) EV concentration in male and female were compared between osteoporotic and non-osteoporotic individuals. (C) Effects of hindlimb unloading and salubrinal on EV concentration in a mouse model of osteoporosis.