Research Paper Volume 13, Issue 15 pp 19486—19509

A combined hypoxia and immune gene signature for predicting survival and risk stratification in triple-negative breast cancer


Figure 1. Schematic diagram of this study. A panel of prognostic hypoxia-related and immune-related genes were determined from the METABRIC, TCGA, and GSE58812 datasets. A comprehensive hypoxia and immune related genes were constituted using the LASSO regression model. The prognostic value, hypoxia and immune status, and therapeutic response were further validated in multiple cohorts.