Research Paper Volume 13, Issue 15 pp 19486—19509

A combined hypoxia and immune gene signature for predicting survival and risk stratification in triple-negative breast cancer

Schematic diagram of this study. A panel of prognostic hypoxia-related and immune-related genes were determined from the METABRIC, TCGA, and GSE58812 datasets. A comprehensive hypoxia and immune related genes were constituted using the LASSO regression model. The prognostic value, hypoxia and immune status, and therapeutic response were further validated in multiple cohorts.

Figure 1. Schematic diagram of this study. A panel of prognostic hypoxia-related and immune-related genes were determined from the METABRIC, TCGA, and GSE58812 datasets. A comprehensive hypoxia and immune related genes were constituted using the LASSO regression model. The prognostic value, hypoxia and immune status, and therapeutic response were further validated in multiple cohorts.