Research Paper Volume 13, Issue 15 pp 19486—19509

A combined hypoxia and immune gene signature for predicting survival and risk stratification in triple-negative breast cancer

Validation of the hypoxia and immune related gene signature in the GSE103091 cohort. (A) Correlation network between the gene signature and HIF1A. Correlation between the risk score and immune score (B) and stromal score (C). (D) Association of MCP-counter-estimated infiltrating cells with the risk score. (E) Comparison of infiltrating immune cells (CIBERSORT) between different risk groups. (F) the expression of immune checkpoint targets between different risk groups. (G–J) GSEA of enriched immune-related signaling in the HIRS-based groups.

Figure 8. Validation of the hypoxia and immune related gene signature in the GSE103091 cohort. (A) Correlation network between the gene signature and HIF1A. Correlation between the risk score and immune score (B) and stromal score (C). (D) Association of MCP-counter-estimated infiltrating cells with the risk score. (E) Comparison of infiltrating immune cells (CIBERSORT) between different risk groups. (F) the expression of immune checkpoint targets between different risk groups. (GJ) GSEA of enriched immune-related signaling in the HIRS-based groups.