Research Paper Volume 13, Issue 15 pp 19908—19919

A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis

circSMARCA5 inhibits DU145 cell proliferative, migrative, and invasive capabilities. circSMARCA5 was upregulated or downregulated in DU145 cells. (A) circSMARCA5 expression in the cells with indicated treatments. (B) DU145 cells’ growth with different treatments. The Transwell assay results showed the migration (C, D) and migration (C, E) of DU145 cells after indicated treatment. Magnification ×100. *, **, *** represent p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, respectively. Assays were performed at least three times.

Figure 2. circSMARCA5 inhibits DU145 cell proliferative, migrative, and invasive capabilities. circSMARCA5 was upregulated or downregulated in DU145 cells. (A) circSMARCA5 expression in the cells with indicated treatments. (B) DU145 cells’ growth with different treatments. The Transwell assay results showed the migration (C, D) and migration (C, E) of DU145 cells after indicated treatment. Magnification ×100. *, **, *** represent p ≤ 0.05, p ≤ 0.01, p ≤ 0.001, respectively. Assays were performed at least three times.