Research Paper Volume 13, Issue 16 pp 20383—20394

Hsa_circ_0134111 promotes osteoarthritis progression by regulating miR-224-5p/CCL1 interaction

Hsa

Figure 5. Hsa_circ_0134111 knockdown counteracts IL-1β-induced chondrocyte death by regulating the miR-224-5p/CCL1 axis. (AC) Representative western blot images and densitometric analysis of CCL1 and CCR8 expression in cultured chondrocytes. (D) Cell viability (CCK-8) assay results. (E, F) Flow cytometric analysis of apoptosis. (GJ) Western blots results. **P<0.01, compared with control; ##P<0.01, compared with IL-1β. ^^P<0.01, compared with IL-1β + hsa_circ_0134111 siRNA1.