Research Paper Volume 13, Issue 16 pp 20383—20394

Hsa_circ_0134111 promotes osteoarthritis progression by regulating miR-224-5p/CCL1 interaction

Hsa

Figure 6. Hsa_circ_0134111 knockdown alleviates the symptoms of OA in vivo. Representative images of knee articular tissue stained with (A) H&E and (B) Safranin O/Fast Green. (C) Subchondral bone thickness measurements. (D) Synovitis scores for knee joints in the different experimental treatments. (E, F) ELISA-based measurements of IL-6 and TNF-α levels in knee synovia. (G) Representative IHC images showing the expression of CCL1 and CCR8 in knee joint tissue. (H) A graphical abstract of this study. **P<0.01, compared with control; ##P<0.01, compared with OA.