Research Paper Volume 13, Issue 16 pp 20716—20737

N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions

Landscape of included m6A regulators. (A) Overview of dynamic biological processes of m6A RNA methylation mediated by “writers”, “erasers” and “readers” in nucleus and cytoplasm. (B) Distribution of “writers”, “erasers” and “readers” among included 26 m6A regulators. (C) Workflow of the study design. Abbreviations: GEO: Gene Expression Omnibus; WGCNA: Weighted Gene Co-expression Network Analysis; GSEA: Gene Set Enrichment Analysis; DEGs: differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; GO: Gene Ontology.

Figure 1. Landscape of included m6A regulators. (A) Overview of dynamic biological processes of m6A RNA methylation mediated by “writers”, “erasers” and “readers” in nucleus and cytoplasm. (B) Distribution of “writers”, “erasers” and “readers” among included 26 m6A regulators. (C) Workflow of the study design. Abbreviations: GEO: Gene Expression Omnibus; WGCNA: Weighted Gene Co-expression Network Analysis; GSEA: Gene Set Enrichment Analysis; DEGs: differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; GO: Gene Ontology.