Research Paper Volume 13, Issue 16 pp 20716—20737

N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions

Identification of hub genes and functional annotation of the WGCNA module highly correlated with clinical traits. (A–C) Scatter plots of eigengenes in the representative modules yellow (A), turquoise (B), and brown (C), which have highly significant correlation between Gene Significance (GS) and Module Membership (MM). (D) PPI network of the top20 hub genes in the module turquoise. The circles with darker red represent higher gene rank. (E) Biological functional annotation of the top20 hub genes in the module turquoise by Geno Ontology (GO) enrichment analysis.

Figure 6. Identification of hub genes and functional annotation of the WGCNA module highly correlated with clinical traits. (AC) Scatter plots of eigengenes in the representative modules yellow (A), turquoise (B), and brown (C), which have highly significant correlation between Gene Significance (GS) and Module Membership (MM). (D) PPI network of the top20 hub genes in the module turquoise. The circles with darker red represent higher gene rank. (E) Biological functional annotation of the top20 hub genes in the module turquoise by Geno Ontology (GO) enrichment analysis.