Research Paper Volume 13, Issue 17 pp 21587—21598

FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma

FOXN3 inhibits the AKT/MDM2/p53 signaling pathway in glioma cells. (A) Protein expression levels of AKT, p-AKT, MDM2 and p53 were examined by Western blotting after transfection with FOXN3 expression vectors in U87MG cells. (B) Protein expression levels of AKT, p-AKT, MDM2 and p53 were determined by Western blotting after transfection with shRNA#1 in SF126 cells. **P

Figure 4. FOXN3 inhibits the AKT/MDM2/p53 signaling pathway in glioma cells. (A) Protein expression levels of AKT, p-AKT, MDM2 and p53 were examined by Western blotting after transfection with FOXN3 expression vectors in U87MG cells. (B) Protein expression levels of AKT, p-AKT, MDM2 and p53 were determined by Western blotting after transfection with shRNA#1 in SF126 cells. **P < 0.01. FOXN3, forkhead box N3; shRNA#1, short hairpin RNA #1 specifically targeting FOXN3; Abbreviations: p-AKT: phosphorylated AKT; MDM2: murine double minute 2.