Research Paper
Regulation of bone and fat balance by fructus ligustri lucidi in ovariectomized mice
Figure 4. FLL promotes the expression of OPG and inhibits the expression of RANKL in OVX mice. Plasma levels of OPG (A) and RANKL (B) were measured by ELISA. The level of OPG significantly increased in the FLL group compared to the OVX group, and the level of RANKL was commensurately attenuated. (C) The ratio of OPG/RANKL was significantly reduced in the OVX group, while it significantly increased after treatment with FLL (n = 10). (D–E) FLL treatment promoted OPG and inhibited RANKL proteins in bone tissue. #P < 0.05 compared with sham; ##P < 0.01 compared with sham; *P < 0.05 compared with OVX; **P < 0.01 compared OVX (n = 3).