Research Paper Volume 13, Issue 18 pp 22164—22175

SLCO1B3 promotes colorectal cancer tumorigenesis and metastasis through STAT3

Ct-SLCO1B3 knockdown inhibits human CRC cell proliferation, migration, and invasion in vitro. (A) Cell migration and invasion abilities evaluated by the Transwell assays. The cells that had migrated to the lower surface of the membrane were counted after 48-hour incubation. n=3; *P B, C) The scratch-wound healing assay evaluated cell migration ability. The width of the wound bed (distance) was measured at 0, 24, and 48 hours after the creation of the scratch wound. (D, E) Cell proliferation evaluated by the MTS assay. n=3; *P

Figure 3. Ct-SLCO1B3 knockdown inhibits human CRC cell proliferation, migration, and invasion in vitro. (A) Cell migration and invasion abilities evaluated by the Transwell assays. The cells that had migrated to the lower surface of the membrane were counted after 48-hour incubation. n=3; *P < 0.05, **P < 0.01 vs. NC. (B, C) The scratch-wound healing assay evaluated cell migration ability. The width of the wound bed (distance) was measured at 0, 24, and 48 hours after the creation of the scratch wound. (D, E) Cell proliferation evaluated by the MTS assay. n=3; *P < 0.05, **P < 0.01, ##P < 0.01 vs. si-NC or NC. NC=si-NC.