Research Paper Volume 13, Issue 18 pp 22164—22175

SLCO1B3 promotes colorectal cancer tumorigenesis and metastasis through STAT3

The effects of Ct-SLCO1B3 knockdown on CRC tumorigenesis in vivo. (A) Characterization of the HCT116 and HT29 cells stably transfected with a lentiviral vector carrying sh-Ct-SLCO1B3 or sh-Control. Bright and fluorescent field cell images (upper panel) and western blot analysis results on Ct-OATP1B3 protein expression (middle and lower panels) are shown. n=3, *P B) Photos of mice bearing subcutaneous tumors. (C) Photos of tumors harvested from the mice. (D) The change in tumor volume with time and the weight of the harvested tumors. *P

Figure 4. The effects of Ct-SLCO1B3 knockdown on CRC tumorigenesis in vivo. (A) Characterization of the HCT116 and HT29 cells stably transfected with a lentiviral vector carrying sh-Ct-SLCO1B3 or sh-Control. Bright and fluorescent field cell images (upper panel) and western blot analysis results on Ct-OATP1B3 protein expression (middle and lower panels) are shown. n=3, *P < 0.05 vs. sh-Control. (B) Photos of mice bearing subcutaneous tumors. (C) Photos of tumors harvested from the mice. (D) The change in tumor volume with time and the weight of the harvested tumors. *P < 0.05.