Research Paper Volume 13, Issue 19 pp 22830—22842

Inhibition of JAK2/STAT3 signaling pathway by panaxadiol limits the progression of pancreatic cancer

Panaxadiol exerted its pro-apoptotic effect via JAK2-STAT3 signaling pathway. (A) Panaxadiol bound to the binding domain on STAT3 distinctly in molecular docking analysis, the right image was the magnified picture from the left. The lowest binding energy with the target site was −5.7 (kcal/mol) among them (B) The surface view of docking analysis in 2D. The corresponding predicted binding site of STAT3 to panaxadiol was Src Homology 2 domain (SH2) (C) The protein expression of JAK2-STAT3 signaling pathway after being incubated with panaxadiol for 24 h. (D) Panaxadiol decreased the ratio of p-STAT3-positive cells in pancreatic cancer cells.

Figure 5. Panaxadiol exerted its pro-apoptotic effect via JAK2-STAT3 signaling pathway. (A) Panaxadiol bound to the binding domain on STAT3 distinctly in molecular docking analysis, the right image was the magnified picture from the left. The lowest binding energy with the target site was −5.7 (kcal/mol) among them (B) The surface view of docking analysis in 2D. The corresponding predicted binding site of STAT3 to panaxadiol was Src Homology 2 domain (SH2) (C) The protein expression of JAK2-STAT3 signaling pathway after being incubated with panaxadiol for 24 h. (D) Panaxadiol decreased the ratio of p-STAT3-positive cells in pancreatic cancer cells.