Research Paper Volume 13, Issue 19 pp 22843—22855

Allicin protects against myocardial I/R by accelerating angiogenesis via the miR-19a-3p/PI3K/AKT axis

Allicin attenuated myocardial ischemia-induced cardiac fibrosis and improved cardiac function. (A) Representative images of the transabdominal ultrasound imaging were presented. Compared with the Control group, the values of LVEF, LVFS, LVAW;d and LVAW;s were significantly decreased in Model group, while LVIDd and LVIDs were increased (*P *P B) Masson staining demonstrated that the areas of cardiac fibrosis of the Model group mice were significantly increased compared with the Control group mice's hearts. And the areas of cardiac fibrosis of the Model group mice were significantly increased compared with Allicin group mice (*P

Figure 1. Allicin attenuated myocardial ischemia-induced cardiac fibrosis and improved cardiac function. (A) Representative images of the transabdominal ultrasound imaging were presented. Compared with the Control group, the values of LVEF, LVFS, LVAW;d and LVAW;s were significantly decreased in Model group, while LVIDd and LVIDs were increased (*P < 0.01). Compared with the Model group, the LVEF, LVFS, LVAW;d and LVAW;s were increased in the Allicin group, whereas LVID;s was decreased (*P < 0.05). (B) Masson staining demonstrated that the areas of cardiac fibrosis of the Model group mice were significantly increased compared with the Control group mice's hearts. And the areas of cardiac fibrosis of the Model group mice were significantly increased compared with Allicin group mice (*P < 0.05).