Research Paper Volume 13, Issue 19 pp 22883—22897

Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing

OA inhibited the breast tumor growth in mice. (A) The total body weights of five mice were compared between the CK group (n = 5) and OA group (n = 5) every day during the feeding process. (B) The bioluminescence intensity of breast tumors in three CK mice and three OA mice was observed by a Tanon-5200 Multifluorescence imaging analysis system. (C) The tumor sizes of three CK mice and three OA mice were measured by rulers. (D) The tumors from the CK group and OA group were weighed and compared (n = 5), **P E) Validation of target gene expression in mice from the CK group and OA group tested by qPCR, *p **P

Figure 7. OA inhibited the breast tumor growth in mice. (A) The total body weights of five mice were compared between the CK group (n = 5) and OA group (n = 5) every day during the feeding process. (B) The bioluminescence intensity of breast tumors in three CK mice and three OA mice was observed by a Tanon-5200 Multifluorescence imaging analysis system. (C) The tumor sizes of three CK mice and three OA mice were measured by rulers. (D) The tumors from the CK group and OA group were weighed and compared (n = 5), **P < 0.01. (E) Validation of target gene expression in mice from the CK group and OA group tested by qPCR, *p < 0.05, **P < 0.01.