Research Paper Volume 13, Issue 19 pp 23096—23107

Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis

Qi Ling regulated the Warburg effect of CRPC cells. Relative glucose consumption (A), pyruvate concentration (B), and lactate production (C) were assessed in PC3-DR and DU145-DR cells. (D and E) mRNA levels of glycolytic components (SLC2A1, PFKP, PKM and LDHA) in PC3-DR and DU145-DR cells were examined by qRT-PCR. Values are mean ± SD. *P **P

Figure 2. Qi Ling regulated the Warburg effect of CRPC cells. Relative glucose consumption (A), pyruvate concentration (B), and lactate production (C) were assessed in PC3-DR and DU145-DR cells. (D and E) mRNA levels of glycolytic components (SLC2A1, PFKP, PKM and LDHA) in PC3-DR and DU145-DR cells were examined by qRT-PCR. Values are mean ± SD. *P < 0.05; **P < 0.01.