Research Paper Volume 13, Issue 19 pp 23096—23107

Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis

SNHG10 was inhibited by Qi Ling and associated with docetaxel resistance of CRPC. (A) RNA level of SNHG10 in PC3-DR and DU145-DR cells was examined by qRT-PCR. (B and C) qRT-PCR was performed to detect the expression level of SNHG10 in PC3 and DU145 cells or their DOC-resistant counterparts (PC3-DR and DU145-DR). (D) RNA level of SNHG10 in 56 docetaxel-free (DR-free) and 44 DR tissues of CRPC patients was examined by qRT-PCR. (E) Kaplan-Meier analysis of the correlation between SNHG10 expression and progression-free survival of CRPC patients. *P **P ***P

Figure 3. SNHG10 was inhibited by Qi Ling and associated with docetaxel resistance of CRPC. (A) RNA level of SNHG10 in PC3-DR and DU145-DR cells was examined by qRT-PCR. (B and C) qRT-PCR was performed to detect the expression level of SNHG10 in PC3 and DU145 cells or their DOC-resistant counterparts (PC3-DR and DU145-DR). (D) RNA level of SNHG10 in 56 docetaxel-free (DR-free) and 44 DR tissues of CRPC patients was examined by qRT-PCR. (E) Kaplan-Meier analysis of the correlation between SNHG10 expression and progression-free survival of CRPC patients. *P < 0.05; **P < 0.01; ***P < 0.001.