Research Paper Volume 13, Issue 19 pp 23133—23148

Short-term high-fat diet favors the appearances of apoptosis and gliosis by activation of ERK1/2/p38MAPK pathways in brain

Association of apoptosis and HFD in mice cerebral cortex at separate times. (A) Western blot analysis of cerebral cortex tissues of mice with HFD and chow diet controls (n = 3 to 4 per group). (B–G) Quantification of PARP (B), Bcl-2 (C), Bax (D), Bad (E), p21 (F), caspase3 (G). GAPDH as a loading control. Values are presented as means ± SD. *P **P

Figure 2. Association of apoptosis and HFD in mice cerebral cortex at separate times. (A) Western blot analysis of cerebral cortex tissues of mice with HFD and chow diet controls (n = 3 to 4 per group). (BG) Quantification of PARP (B), Bcl-2 (C), Bax (D), Bad (E), p21 (F), caspase3 (G). GAPDH as a loading control. Values are presented as means ± SD. *P < 0.05 and **P < 0.01 versus chow diet; one-way ANOVA by Tukey’s test.