Research Paper Volume 13, Issue 19 pp 23245—23261

Identification of potential target genes of non-small cell lung cancer in response to resveratrol treatment by bioinformatics analysis

Selection of hub genes. PPI network was analyzed by cytohubba, a plugin of Cytoscape. A node represents a gene. The genes reduced in NSCLC tissue were shown in green color. The genes increased in NSCLC tissue were shown in red color; at the same time, the genes which down-regulated in A549 by resveratrol were posted in triangles, and the genes which up-regulated by resveratrol were posted in shape “V”. The hub genes with higher scores were demonstrated with larger size.

Figure 3. Selection of hub genes. PPI network was analyzed by cytohubba, a plugin of Cytoscape. A node represents a gene. The genes reduced in NSCLC tissue were shown in green color. The genes increased in NSCLC tissue were shown in red color; at the same time, the genes which down-regulated in A549 by resveratrol were posted in triangles, and the genes which up-regulated by resveratrol were posted in shape “V”. The hub genes with higher scores were demonstrated with larger size.